Oral administration is now first choice in the treatment of impotence. Smooth muscle relaxation in the corpus cavernosum and the supplying blood vessels mediated by nitric oxide increases the amount of cGMP in the tissues. Normally, cGMP is broken down by the enzyme phosphodiesterase V. Large studies have shown that up to 80% of patients with impotence respond well to drugs that inhibit phosphodiesterase type V (PDE5-I).
Canadian Sildenafil (Viagra) inhibits phosphodiesterase V and therefore strengthen erections. Drugs that inhibit phosphodiesterase V have a vasodilatory effect, and one must exercise caution in treating patients with heart disease. Light to moderate angina pectoris is not a contraindication, but it’s taken with nitrates is contraindicated!
In the following groups of patients it is prohibited to use sildenafil:
- Persons under 18 years
- Those who suffer from a problem where sex, or other exercise, is not recommended
- Have had a recent heart attack or stroke
- Suffering from high blood pressure (hypertension)
- Suffering from liver problems or eye diseases
- Are allergic to any of the ingredients in Viagra
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