Per-Protocol Analysis and Canadian pharmacy viagra
In the evaluation of outcomes for the per-protocol population, few patients were excluded (ie, the per-protocol population was similar to the ITT population) [excluded from the extended-care analysis, 9 patients; excluded from the relapse analysis, 26 patients (including 8 patients who were excluded from the extended-care analysis who continued as outpatients)]. A prerandomization FEV1 of > 70% predicted was the most common reason for exclusion from the per-protocol analyses. The results of the per-protocol analyses were consistent with those of the ITT analyses.
Influence of Baseline Characteristics
For each outcome (ie, extended care and relapse), the effects of zafirlukast were not influenced by race, age, initial ED FEV1, response to the initial ED (3-agonist therapy, or the use of oral steroids within 14 days of ED Viagra Canada enrollment. Gender did not influence either the need for extended care or the time to relapse in this study, and the greater number of men in the ED Z160 group did not impact the need for extended-care study results. Additional analysis revealed a relationship between therapy with inhaled corticosteroids (ICSs) and that with zafirlukast in the outpatient portion of the study, with patients not receiving ICSs responding better to zafirlukast. A similar relationship was not found in the ED portion of the study. Propensity analysis indicated that the effect of zafirlukast on relapse was not influenced by patient or clinical characteristics at the time of ED discharge.
Safety and Health care mall
The number of adverse events was similar between the zafirlukast and placebo treatment groups per trial period. The most common adverse event was headache. In the ED period, headache occurred in two patients (1%) each in the Z160 and Z20 treatment groups, and in five patients (2%) in the placebo group. In the outpatient period, headache occurred in 40 patients (15%) treated with zafirlukast and in 33 patients (12%) treated with placebo. After 4 weeks of randomized treatment, four zafirlukast-treated patients (1%) and six placebo-treated patients (2%) had alanine aminotransferase levels greater than two times the upper limit of normal.